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Related Experiment Video

Updated: May 30, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

Target repurposing for neglected diseases.

Michael P Pollastri¹, Robert K Campbell

¹Northeastern University, Department of Chemistry and Chemical Biology, Hurtig 102, 360 Huntington Avenue, Boston, MA 02115, USA. m.pollastri@neu.edu

Future Medicinal Chemistry

|August 24, 2011

Summary

This summary is machine-generated.

Target repurposing matches pathogen targets with human ones to accelerate drug discovery for neglected infectious diseases. This strategy leverages existing knowledge to develop new therapeutics efficiently.

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Area of Science:

Global Health
Drug Discovery
Infectious Diseases

Background:

Infectious diseases pose a significant global health burden, particularly in developing nations.
Commercial drug discovery often neglects diseases prevalent in developing regions due to high costs.
Novel, cost-effective therapeutic discovery methods are urgently needed.

Purpose of the Study:

To introduce and describe the strategy of target repurposing for neglected disease drug discovery.
To highlight the practical application of target repurposing using case studies.
To demonstrate how existing knowledge can accelerate the development of new therapeutics.

Main Methods:

Identifying homologous human and pathogen targets.
Leveraging existing medicinal chemistry, structural biology, and biochemistry data from human targets.
Applying this knowledge to initiate and advance drug discovery programs against pathogen targets.

Main Results:

Target repurposing provides a pragmatic approach to discovering new therapeutics.
Existing knowledge bases for human targets can significantly accelerate drug discovery for infectious diseases.
Three case studies illustrate the successful application of this strategy.

Conclusions:

Target repurposing is a valuable tool for initiating and prosecuting drug discovery for neglected diseases.
This strategy offers a cost-effective and efficient pathway to develop urgently needed therapeutics.
Further exploration and application of target repurposing can address critical global health challenges.