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Related Concept Videos

Microbiome of the Eye01:22

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
Antibiotic Selection00:57

Antibiotic Selection

Overview
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
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Related Experiment Video

Updated: May 30, 2026

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
07:24

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Published on: February 6, 2021

Antibiotic resistance in ocular bacterial pathogens.

S Sharma1

  • 1Laboratory Services, LVPEI-Network, L V Prasad Eye Institute, Patia, Bhubaneswar, Orissa - 751 024, India. savitri@lvpei.org

Indian Journal of Medical Microbiology
|August 24, 2011
PubMed
Summary

Antibiotic resistance in eye infections is rising, concerning ophthalmologists. New ophthalmic antibiotics like besifloxacin may offer hope, but judicious antibiotic use is crucial to combat resistance.

Area of Science:

  • Ophthalmology
  • Microbiology
  • Infectious Diseases

Background:

  • Bacterial eye infections are common, with various antibiotic administration routes available.
  • Increasing antibiotic resistance in ocular pathogens mirrors systemic resistance trends.
  • Emergence of fluoroquinolone-resistant ocular bacteria is a growing concern.

Purpose of the Study:

  • To highlight the escalating issue of antibiotic resistance in ocular bacterial infections.
  • To discuss the potential of new ophthalmic-specific antibiotics.
  • To emphasize the importance of judicious antibiotic use in preventing resistance.

Main Methods:

  • Review of current literature on ocular bacterial infections and antibiotic resistance.
  • Analysis of trends in antibiotic resistance patterns, including fluoroquinolones.

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Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

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Related Experiment Videos

Last Updated: May 30, 2026

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
07:24

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Published on: February 6, 2021

Conjunctival Commensal Isolation and Identification in Mice
07:52

Conjunctival Commensal Isolation and Identification in Mice

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Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

  • Discussion of novel therapeutic strategies and preventative measures.

    • Main Results:

    • Antibiotic resistance among ocular pathogens is increasing globally.
    • Prior topical antibiotic use is linked to the emergence of resistant ocular bacteria.
    • Newer agents like besifloxacin, developed for ophthalmic use, may circumvent existing resistance mechanisms.

    Conclusions:

    • Judicious antibiotic use is essential to control and prevent the further development of resistant ocular pathogens.
    • Development of novel antibacterial agents for ophthalmic use is critical.
    • Ophthalmologists must consider resistance patterns when selecting antibiotic therapies.