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Related Concept Videos

Spinal Nerves: Plexus I01:22

Spinal Nerves: Plexus I

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Spinal Nerves: Plexus II

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Papillary Dermis

Dermis
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Related Experiment Video

Updated: May 30, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Multiple isolated cutaneous plexiform schwannomas.

Enas A S Attia1, Marwa Yassin, Mohamed A Lasheen

  • 1Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. annosah1974@yahoo.com

Indian Journal of Dermatology, Venereology and Leprology
|August 24, 2011
PubMed
Summary
This summary is machine-generated.

This study reports a rare case of multiple cutaneous plexiform schwannomas in a patient without neurofibromatosis type 2 (NF2). These skin tumors were isolated and confined to the dermis, differing from typical NF2 presentations.

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Area of Science:

  • Dermatology
  • Oncology
  • Neuropathology

Background:

  • Plexiform schwannomas are rare neurogenic tumors originating from skin and subcutaneous tissue.
  • Multiple schwannomas often suggest an association with neurofibromatosis type 2 (NF2).

Observation:

  • A 50-year-old male presented with multiple papulo-nodular cutaneous lesions on his arms.
  • Histopathology revealed dermal, multinodular, well-circumscribed schwannomas with positive S-100 and neuron-specific enolase staining.
  • Audiogram and MRI excluded acoustic neuroma, ruling out NF2.

Findings:

  • The case presented multiple, bilateral, isolated cutaneous plexiform schwannomas.
  • These tumors were confined to the dermis and not associated with NF2.
  • This presentation is exceptionally rare in medical literature.

Implications:

  • Highlights the existence of isolated cutaneous plexiform schwannomas distinct from NF.
  • Emphasizes the importance of thorough histopathological and imaging evaluation for accurate diagnosis.
  • Contributes to understanding the spectrum of schwannoma presentations.