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Updated: May 30, 2026

Embryo Microinjection and Electroporation in the Chordate Ciona intestinalis
Published on: October 16, 2016
The protochordate Ciona intestinalis has a protein like full-length vertebrate fibrinogen
1Department of Chemistry & Biochemistry, University of California, San Diego, Calif., USA. rdoolittle@ucsd.edu
Abstract:
In a recent review, a putative fibrinogen-like protein in the protochordate Ciona intestinalis was noted. Unfortunately, computer-directed splicing had omitted several exons, mistakenly generating a single long polypeptide chain. In fact, 3 consecutive genes exist, the translated versions of which are homologous to individual vertebrate fibrinogen chains. The circulating form is likely a 6-chain covalent dimer, just as occurs in vertebrates.
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