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Azaphenanthrene alkaloids with antitumoral activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae)
Ana Silvia Suassuna Carneiro Lúcio1, Jackson Roberto Guedes da Silva Almeida, José Maria Barbosa-Filho
1Laboratory of Pharmaceutical Technology, Federal University of Paraiba, João Pessoa, PB, Brazil. asilviasuassuna@gmail.com
Abstract:
Phytochemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith led to isolation of three azaphenanthrene alkaloids: eupolauramine, sampangine and imbiline 1. Their chemical structures were established on the basis of spectroscopic data from IR, HR-ESI-MS, NMR (including 2D experiments) and comparison with the literature. Sampangine and imbiline 1 are being described in the Anaxagorea genus for the first time. Eupolauramine and sampangine show concentration-dependent antitumoral activity in leukemic cells K562 with IC(50) of 18.97 and 10.95 µg/mL, respectively.
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