Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stereoisomerism02:52

Stereoisomerism

Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
Photochemical Electrocyclic Reactions: Stereochemistry01:26

Photochemical Electrocyclic Reactions: Stereochemistry

The absorption of UV–visible light by conjugated systems causes the promotion of an electron from the ground state to the excited state. Consequently, photochemical electrocyclic reactions proceed via the excited-state HOMO rather than the ground-state HOMO. Since the ground- and excited-state HOMOs have different symmetries, the stereochemical outcome of electrocyclic reactions depends on the mode of activation; i.e., thermal or photochemical.
Selection Rules: Photochemical Activation
E1 Reaction: Stereochemistry and Regiochemistry02:43

E1 Reaction: Stereochemistry and Regiochemistry

One of the critical aspects of the E1 reaction mechanism, as also observed in E2, is the regiochemistry, with multiple regioisomers obtained as products. In the example discussed, the presence of water as a weak base favors elimination over substitution to generate two alkenes. Given that alkenes’ stability increases with the number of alkyl groups across the double bond, typically, E1 reactions lead to the Zaitsev product, for this is more substituted and stable than the Hofmann product.
E2 Reaction: Stereochemistry and Regiochemistry02:43

E2 Reaction: Stereochemistry and Regiochemistry

Elimination reactions of alkyl halides can yield one or more alkenes depending on the specific regiochemical and stereochemical considerations. While the regiochemistry of the reaction governs the location of the double bond in the product, the stereochemical requirements often influence the geometry.
When a substrate with two different β hydrogens undergoes an E2 elimination, the presence of a strong base can yield two regioisomeric alkenes. The more-substituted alkene is the major product and...
Stereoisomers02:32

Stereoisomers

On the basis of mirror symmetry, stereoisomers of an organic molecule can be further classified into diastereomers and enantiomers. Diastereomers are stereoisomers that are not mirror images of each other. Substituted alkenes, such as the cis and trans isomers of 2-butene, are diastereomers, as these molecules exhibit different spatial orientations of their constituent atoms, are not mirror images of each other, and do not interconvert. Here, the interconversion is suppressed due to restricted...
SN1 Reaction: Stereochemistry02:15

SN1 Reaction: Stereochemistry

This lesson provides an in-depth discussion of the stereochemical outcomes in an SN1 reaction.
In the first step of an SN1 reaction, the bond between the electrophilic carbon and the leaving group ionizes to generate the carbocation intermediate. The second step of the mechanism is the nucleophilic attack.
In the formed carbocation, the positively charged carbon is sp2 hybridized with a trigonal planar geometry. As all the three substituents lie on the same plane, a plane of symmetry for the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Context Rules! Special Issue on "Physical Organic Chemistry: Never Out of Style".

The Journal of organic chemistry·2026
Same author

Isoelectric focusing and immunofixation can find the hidden light chain in IgD paraproteins.

Pathology·2025
Same author

Vutrisiran in Transthyretin Amyloidosis: A Pooled Safety Analysis of HELIOS-A and HELIOS-B.

JACC. Advances·2025
Same author

OGG1 Preserves Endothelial-Dependent Vasodilation and Regulates the Frequency and Spatial Area of Endothelial Calcium Signals.

Biomolecules·2025
Same author

Regioselective, Lewis Acid-Catalyzed Ring-Openings of 2,3-Aziridyl Alcohols with Azoles.

The Journal of organic chemistry·2025
Same author

Flow-Dependent Modulation of Endothelial Ca<sup>2+</sup> Dynamics by Small Conductance Ca<sup>2+</sup>-Activated K<sup>+</sup> Channels in Mouse Carotid Arteries.

Biomedicines·2025

Related Experiment Video

Updated: May 30, 2026

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers
08:51

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers

Published on: August 18, 2017

Bürgenstock 2011: a stereochemical sojourn.

Mark S Taylor

    Nature Chemistry
    |August 24, 2011
    PubMed
    Summary
    This summary is machine-generated.

    Stereochemistry is a unifying theme for diverse chemists at the Bürgenstock conference. This annual meeting fosters intensive, interdisciplinary discussions across various chemical sub-disciplines.

    More Related Videos

    Fully Autonomous Characterization and Data Collection from Crystals of Biological Macromolecules
    07:11

    Fully Autonomous Characterization and Data Collection from Crystals of Biological Macromolecules

    Published on: March 22, 2019

    Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
    07:36

    Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy

    Published on: November 9, 2019

    Related Experiment Videos

    Last Updated: May 30, 2026

    Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers
    08:51

    Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers

    Published on: August 18, 2017

    Fully Autonomous Characterization and Data Collection from Crystals of Biological Macromolecules
    07:11

    Fully Autonomous Characterization and Data Collection from Crystals of Biological Macromolecules

    Published on: March 22, 2019

    Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
    07:36

    Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy

    Published on: November 9, 2019

    Area of Science:

    • Organic Chemistry
    • Physical Chemistry
    • Chemical Biology

    Background:

    • The Bürgenstock conference is a long-standing scientific meeting.
    • It serves as a platform for chemists from various fields.

    Framework:

    • Stereochemistry is identified as a key unifying concept.
    • The conference encourages interdisciplinary dialogue.

    Implementation:

    • Chemists from different sub-disciplines convene annually.
    • Discussions are characterized by their intensity and breadth.

    Implications:

    • Fosters collaboration and knowledge exchange among chemists.
    • Highlights the central role of stereochemistry in modern chemistry.
    • Strengthens the interdisciplinary nature of chemical sciences.