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Related Concept Videos

Drug Administration and Therapy Phases: Overview01:26

Drug Administration and Therapy Phases: Overview

Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
Principles of Drug Action01:24

Principles of Drug Action

Drugs are chemical substances that modify biological responses by interacting with macromolecular targets such as receptors, ion channels, transporters, and enzymes. Pharmacodynamics describes the course of action of drugs leading to the physiological effect at a specific site in the body.
Drugs can be agonists or antagonists. Like the endogenous ligands, agonists always bind and activate the target to produce a cellular response. Agonist binding induces a conformational change which in turn...
Biopharmaceutics and Pharmacokinetics: Overview01:28

Biopharmaceutics and Pharmacokinetics: Overview

Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the appropriate...
Biopharmaceutical Factors Influencing Drug Product Design: Overview01:22

Biopharmaceutical Factors Influencing Drug Product Design: Overview

Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though pharmacologically...
Pharmaceutical Equivalents01:26

Pharmaceutical Equivalents

As defined by regulatory standards, pharmaceutical equivalents require generic drug products to have identical dosage forms and chemically identical active pharmaceutical ingredients (APIs). They must adhere to compendial or applicable standards for potency, content uniformity, disintegration times, and dissolution rates. In the case of modified-release dosage forms, variations in drug content are permissible as long as the delivered amount remains consistent with the innovator drug product.
Drug Products: Biologics, Biosimilars and Interchangeables01:28

Drug Products: Biologics, Biosimilars and Interchangeables

Biologics, derived from living sources such as humans, animals, or microorganisms, represent a significant category of pharmaceuticals. These complex molecules, developed through advanced biotechnological methods or purified from natural sources, include essential medical treatments like insulin and growth hormones. The complexity of biologics arises from their large molecular structures and the intricate processes required for their production, making them distinct from conventional...

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Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
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Published on: December 1, 2020

Getting physical to fix pharma.

Patrick R Connelly, T Minh Vuong, Mark A Murcko

    Nature Chemistry
    |August 24, 2011
    PubMed
    Summary
    This summary is machine-generated.

    High-throughput screening in drug discovery yields many compounds, yet success rates remain low. Improving our fundamental understanding of molecular physical chemistry is crucial for enhancing pharmaceutical research and development outcomes.

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    Area of Science:

    • Medicinal Chemistry
    • Physical Chemistry
    • Pharmaceutical Sciences

    Background:

    • Modern pharmaceutical research and development (R&D) utilizes powerful technologies for synthesizing and testing numerous novel compounds.
    • Despite advancements, the industry faces a persistently high failure rate in R&D, indicating a significant gap in predictive success.

    Discussion:

    • The high attrition rate in drug discovery necessitates a deeper exploration of the underlying physical chemical principles governing molecular behavior.
    • A comprehensive understanding of molecular interactions and properties is essential for optimizing compound selection and predicting efficacy.
    • Bridging the gap between compound synthesis and clinical success requires a robust foundation in physical chemical behavior analysis.

    Key Insights:

    • Enhanced understanding of fundamental physical chemical properties of molecules is identified as a critical factor for improving drug discovery success rates.
    • Focusing on molecular behavior can lead to more informed decisions in the early stages of pharmaceutical R&D.
    • This approach promises to significantly reduce the high failure rate currently plaguing the pharmaceutical industry.

    Outlook:

    • Future drug discovery efforts should prioritize the integration of advanced physical chemical analyses into R&D pipelines.
    • Continued research into molecular behavior will pave the way for more efficient and successful development of new therapeutics.
    • This paradigm shift aims to accelerate the delivery of effective medicines to patients by improving the predictability of R&D outcomes.