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Updated: May 30, 2026

Longitudinal Micro-Computed Tomography Image Analysis for User-Defined Region of Interest in Critical-Sized Bone Defects
Published on: June 24, 2025
Comparison between cone-beam and multislice computed tomography for identification of simulated bone lesions
Bruno Felipe Gaia1, Marcelo Augusto Oliveira de Sales, Andréia Perrella
1Stomatology Department, Dental School, University of São Paulo, São Paulo, SP, Brazil.
Multislice (MSCT) and cone beam (CBCT) computed tomography show similar accuracy in diagnosing simulated mandibular bone lesions. Both imaging techniques, using cross-sectional and multiplanar reconstruction slices, are highly effective for bone lesion evaluation.
Area of Science:
- Dentistry
- Radiology
- Oral and Maxillofacial Surgery
Background:
- Multislice computed tomography (MSCT) and cone beam computed tomography (CBCT) are widely used for maxillofacial imaging.
- Limited research exists comparing MSCT and CBCT for evaluating simulated mandibular bone lesions.
Purpose of the Study:
- To compare the diagnostic accuracy of MSCT and CBCT in identifying simulated mandibular bone lesions.
- To evaluate the effectiveness of cross-sectional images versus axial/multiplanar reconstruction (MPR) slices from both techniques.
Main Methods:
- Simulated bone lesions of varying dimensions, shapes, and locularity were created in 15 dry mandibles.
- Images were acquired using both MSCT and CBCT with cross-sectional and axial/MPR protocols.
- Image interpretation was performed independently by examiners.
Main Results:
- CBCT and MSCT demonstrated comparable accuracy in depicting cortical bone involvement, with high sensitivity and specificity (p < 0.005).
- No significant differences in sensitivity or specificity were found between axial/MPR and cross-sectional images.
- Both techniques accurately identified the number of simulated lesions, with CBCT performing similarly to MSCT.
Conclusions:
- Cross-sectional slices and axial/MPR images from both MSCT and CBCT exhibit high accuracy for diagnosing bone lesions.
- CBCT is a viable alternative to MSCT for evaluating simulated mandibular bone lesions.
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