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Intrauterine Drug Delivery Systems01:21

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In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
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Updated: May 30, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
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Published on: November 20, 2015

Scheduled deliveries: avoiding iatrogenic prematurity.

Nancy Chescheir1, M Kathryn Menard

  • 1Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, USA.

American Journal of Perinatology
|August 24, 2011
PubMed
Summary

Delaying elective deliveries before 39 weeks improves neonatal outcomes. Some conditions previously requiring early delivery may be safely managed later in pregnancy, reducing neonatal risks and healthcare costs.

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Area of Science:

  • Obstetrics and Gynecology
  • Neonatal Medicine
  • Evidence-Based Medicine

Background:

  • Elective deliveries before 39 weeks gestation are associated with adverse neonatal outcomes.
  • Certain clinical conditions often lead to deliveries before 39 weeks, despite potential risks.
  • Late preterm and early term births significantly increase neonatal morbidity and healthcare expenses.

Purpose of the Study:

  • To review clinical scenarios prompting delivery before 39 weeks gestation.
  • To evaluate the evidence for delaying delivery in specific conditions.
  • To identify strategies for optimizing maternal and neonatal outcomes in these cases.

Main Methods:

  • Systematic review of existing literature on maternal, fetal, and neonatal risks.
  • Analysis of clinical guidelines and practice patterns for early term deliveries.
  • Focus on evidence-based approaches to managing pregnancies near term.

Main Results:

  • Evidence suggests some conditions previously necessitating early delivery can be safely managed later.
  • Delaying delivery until after 39 weeks can mitigate neonatal risks associated with early birth.
  • Careful risk-benefit assessment is crucial when considering delivery before 39 weeks.

Conclusions:

  • Delivery before 39 weeks should only occur when maternal/fetal risks outweigh neonatal risks of early birth.
  • Optimizing management strategies can improve outcomes for both mothers and newborns.
  • Further research into evidence-based practices for late preterm and early term deliveries is warranted.