Related Experiment Video
Updated: May 30, 2026

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
Published on: April 7, 2023
[FABP2 gene polymorphism and metabolic disorder of lipids in the middle aged and aged population]
Yaqi Liu1, Chengkai Zhai, Pei Cao
1School of Public Health, Southeast University, Nanjing 210009, China. liuyaqi7@gmail.com
Objective:
To learn the gene distribution of fatty acid binding protein gene (FABP2) and the mutation frequency of wild type A54T in FABP2 gene in the people with abnormal lipid metabolism to detect from molecular level the relationship between FABP2 gene polymorphism and metabolic disorder of lipids, and to investigate genetic factors and the pathogenesis of lipid metabolic disorders in the middle aged and aged people.
Methods:
The polymorphism of FABP2 gene was analyzed by RELP (Restriction fragment length polymorphism) technique. The relationship between FABP2 polymorphism and the risk of dyslipidemia in 410 middle aged and aged people was investigated.
Results:
Mutation frequency of FABP2 gene in the people with dyslipidemia was 71.9%, significantly higher than that in the people with normal blood lipids (P < 0.05). Compared with individuals with wild type homozygote (Ala54/Ala54), the serum TC and TG of individuals with mutational heterozygote (Ala54/Thr54) or mutational homozygote (Thr54/Thr54) were distinctly higher, and serum HDL-C of them were distinctly lower (P < 0.05).
Conclusion:
FABP2 gene polymorphism might be one of factors for genetic susceptibility in metabolic disorder of lipids. The risk of occurring lipid metabolic disorders in individuals carrying mutational FABP2 gene (Ala54/Thr54, Thr54/Thr54) might be higher than those carrying wild type homozygote (Ala54/ Ala54) while exposed to the same environment.
Related Concept Videos
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Overview of Lipid Metabolism
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Pharmacogenetics of Drug Metabolism: Overview
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
