Related Experiment Video
Updated: May 30, 2026
A Murine Model of Hyperlipidemia-Induced Heart Failure with Preserved Ejection Fraction
Published on: March 29, 2024
[Effects of resveratrol on lipid metabolism in C57BL/6J mice]
Yahao Ren1, Yanxi Li, Yue Zhao
1Department of Nutrition and Food hygiene, School of Public Health, China Medical University, Shenyang 110001, China. renyahao0512@sohu.com
Objective:
To investigate the effects of resveratrol on serum and liver lipids in C57BL/6J mice.
Methods:
30 male C57BL/6J mice were randomly assigned to the following three groups: control group given a normal diet, high-fat diet group and resveratrol group (22.5 mg/kg BW) were given high fat diet. the resveratrol were dissolved in 0.5% sodium carboxymethyl cellulose and were given to the Resveratrol group by intragastric administration. The levels of serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), the levels of TG and TC in liver, and the pathological changes of liver were measured after the treatment lasted for 8 weeks.
Results:
The serum TC, LDL-C, HDL-C levels of high-fat diet and resveratrol groups were higher than those of control group (P < 0.05), and the serum TC and LDL-C levels of high-fat diet were also higher than those of resveratrol group (P < 0. 05). But the serum TG levels of high-fat diet and resveratrol groups were lower than those of control group (P < 0.05). The TC content of liver in high-fat diet group were higher than those of control and resveratrol groups (P < 0.05).
Conclusion:
The TC content in C57BL/6J mice can be decreased by resveratrol (22.5 mg/kg BW).
