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Updated: May 30, 2026

Quantitative Determination of De Novo Fatty Acid Synthesis in Brown Adipose Tissue Using Deuterium Oxide
Published on: May 12, 2023
Structure determination of the nonlinear hydrocarbon chains C9H3 and C11H3 by deuterium labeling
Dongfeng Zhao1, Mohammad Ali Haddad, Harold Linnartz
1Institute for Lasers, Life, and Biophotonics, VU University Amsterdam, De Boelelaan 1081, NL 1081 HV Amsterdam, The Netherlands. d.zhao@vu.nl
Abstract:
A systematic deuterium labeling experiment is presented that aims at an unambiguous determination of the geometrical ground state structure of the C(9)H(3) and C(11)H(3) hydrocarbon chains. Cavity ring-down spectroscopy and special plasma expansions constituting C/H, C/D, and C/H/D are used to record optical transitions of both species and their (partially) deuterated equivalents in the 19,000 cm(-1) region. The number of observed bands, the quantitative determination of isotopic shifts, and supporting calculations show that the observed C(9)H(3) and C(11)H(3) spectra originate from HC(4)(CH)C(4)H and HC(4)[C(C(2)H)]C(4)H species with C(2v) symmetry. This result illustrates the potential of deuterium labeling as a useful approach to characterize the molecular structure of nonlinear hydrocarbon chains.
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