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Hyperuricemia and increased risk of ischemic heart disease in a large Chinese cohort

Shao-Yuan Chuang1, Jiunn-Horng Chen, Wen-Ting Yeh

  • 1Institute of Population Health Sciences, National Health Research Institutes, Miaoli country, Taiwan.

International Journal of Cardiology
|August 25, 2011
PubMed

Insights

High serum uric acid (SUA) is an independent predictor of ischemic heart disease (IHD) in ethnic Chinese. This association holds even in individuals without metabolic syndrome risk factors, suggesting hyperuricemia is a potential cardiovascular risk factor.

Area of Science:

  • Cardiovascular Epidemiology
  • Metabolic Syndrome Research
  • Clinical Biochemistry

Background:

  • Serum uric acid (SUA) levels are debated as independent predictors of ischemic heart disease (IHD).
  • Confirmation would imply a role for uric acid in cardiovascular disease pathogenesis.
  • This study focuses on ethnic Chinese, a population with generally lower cardiovascular disease (CVD) risk.

Purpose of the Study:

  • To investigate if SUA independently predicts IHD in ethnic Chinese.
  • To determine if this association persists in individuals without metabolic risk factors.

Main Methods:

  • A cohort of 128,569 adults in Taiwan (1994-1996) was followed until 2002.
  • Exclusion criteria included pre-existing heart disease, stroke, renal disease, or cancer.
  • Cox proportional hazard models analyzed the association between SUA and IHD events, identified via hospital records and death registries.

Main Results:

  • A total of 2049 IHD events occurred. Men had a higher incidence than women.
  • Hyperuricemia (SUA ≥ 7.0/≥ 6.0 mg/dL) was associated with increased IHD risk (adjusted HRs: 1.25 for men, 1.19 for women).
  • A significant association between hyperuricemia and IHD persisted in the low-risk population (adjusted HR: 1.54).

Conclusions:

  • Hyperuricemia is independently associated with IHD development in the general population.
  • This independent association was also observed in individuals without NCEP ATPIII metabolic risk factors.
  • Hyperuricemia should be considered a potential risk factor for IHD.
Abstract

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