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Allergic Reactions

Allergic Reactions

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Updated: May 30, 2026

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Allergy to hazelnut in adults: a two-step study.

G Paşaoğlu¹, D Mungan, Z Misirligil

¹Ankara University, School of Medicine, Department of Allergy, Ankara, Turkey. guldenpasaoglu@yahoo.com

Allergologia Et Immunopathologia

|August 25, 2011

Summary

Hazelnut allergy prevalence is low, but skin tests alone are insufficient for diagnosis. A double-blind, placebo-controlled food challenge is crucial for confirming hazelnut allergy.

Area of Science:

Allergy and Immunology
Clinical Nutrition
Food Science

Background:

Hazelnut consumption is high in Turkey, yet its allergy prevalence remains unestablished.
This study aimed to determine hazelnut sensitization rates and clinical significance in adults.

Purpose of the Study:

To investigate the prevalence of hazelnut sensitization in a Turkish adult population.
To verify the clinical relevance of sensitization through double-blind, placebo-controlled food challenges (DBPCFC).

Main Methods:

Conducted prick-to-prick skin tests with fresh hazelnut on 904 allergy patients.
Evaluated 20 patients with positive history or skin tests, including specific IgE measurements.
Performed DBPCFC on 11 selected patients to confirm hazelnut allergy.

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Main Results:

Skin test sensitization was observed in 1.8% of individuals.
Specific IgE positivity was low (3/20 patients).
DBPCFC confirmed hazelnut allergy in 63.6% (7/11) of participants, with mild to moderate reactions.

Conclusions:

Skin test sensitization prevalence for hazelnut is approximately 1.76%.
A positive history combined with a positive skin test suggests potential hazelnut allergy.
Oral food challenges are essential for definitive hazelnut allergy diagnosis.