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OMICS-strategies and methods in the fight against doping
1Doping Control Laboratory, AIT Seibersdorf Laboratories, A-2444 Seibersdorf, Austria.
Forensic Science International
|August 25, 2011
Summary
OMICS methods offer potential for indirect anti-doping detection of prohibited substances and methods. However, the complexity and variability of human biological systems have limited their routine application in sports doping control.
Area of Science:
- Sports Science
- Molecular Biology
- Biomarker Discovery
Background:
- OMICS methods (transcriptomics, proteomics, metabolomics) are increasingly used in life sciences research.
- Their application in anti-doping is driven by the difficulty in directly detecting certain prohibited substances and methods.
- Traditional targets include human growth hormone (hGH), recombinant erythropoietin (rhEpo), and autologous blood transfusions.
Purpose of the Study:
- To review research on OMICS-based approaches for indirect doping detection.
- To discuss the challenges and future strategies for implementing OMICS in routine anti-doping control.
Main Methods:
- Review of previous and recent research projects utilizing OMICS technologies for anti-doping.
- Analysis of biomarker discovery for indirect detection of doping agents.
- Discussion of challenges related to biological complexity and inter-individual variability.
Main Results:
- While OMICS platforms theoretically offer ideal biomarker discovery, direct application in routine doping control has been limited.
- Existing non-OMICS parameters, like the athlete's biological passport, are currently in use.
- The complexity of human transcriptomes, proteomes, and metabolomes presents a significant hurdle.
Conclusions:
- OMICS methods hold promise for indirect doping detection, potentially identifying multiple substances with similar mechanisms.
- Overcoming the inherent complexity and variability of biological systems is crucial for successful implementation.
- Future strategies are needed to enhance the efficiency and application of OMICS in anti-doping control.
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