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Phagocytosis of Apoptotic Cells

Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
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Cells respond to damage and stress through highly coordinated processes that decide whether they survive or undergo controlled self-destruction. Two major pathways involved in this regulation are apoptosis, a type of programmed cell death, and autophagy, a survival mechanism that helps cells adapt to adverse conditions.ApoptosisApoptosis removes aged or injured cells to maintain tissue balance. During this process, the cell shrinks, chromatin condenses and fragments, and membrane-bound...

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Adipo-Clear: A Tissue Clearing Method for Three-Dimensional Imaging of Adipose Tissue
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Does killing adipocytes kill the bad macrophages?

Anthony W Ferrante1

  • 1Columbia University, The Naomi Berrie Diabetes Center, New York, New York 10032, USA. awf7@columbia.edu

Endocrinology
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No abstract available in PubMed .

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