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Late-onset inner retinal dysfunction in mice lacking sigma receptor 1 (σR1)
Yonju Ha1, Alan Saul, Amany Tawfik
1Department of Cellular Biology and Anatomy, Medical College of Georgia, Georgia Health Sciences University, Augusta, Gerogia, USA.
Investigative Ophthalmology & Visual Science
|August 25, 2011
Summary
The absence of sigma receptor 1 (σR1) in mice leads to late-onset retinal dysfunction and optic neuropathy. This study highlights σR1
Area of Science:
- Ophthalmology
- Neuroscience
- Molecular Biology
Background:
- Sigma receptor 1 (σR1) is a molecular chaperone abundant in the eye.
- Previous research suggests σR1 involvement in lens cell survival, intraocular pressure (IOP) regulation, and retinal neuroprotection.
Purpose of the Study:
- To investigate the effects of σR1 absence on ocular development, structure, and function.
- To determine the role of σR1 in maintaining retinal health and preventing optic neuropathy.
Main Methods:
- Utilized wild-type, heterozygous, and homozygous σR1 knockout mice.
- Conducted comprehensive electrophysiological testing (ERG) and IOP measurements.
- Performed light and electron microscopy, morphometric analysis, and apoptosis detection.
Main Results:
- No significant morphological or IOP differences were observed in σR1 knockout mice compared to wild-type.
- Late-onset retinal dysfunction, characterized by decreased ERG b-wave amplitudes and diminished scotopic threshold responses, was detected by 12 months.
- Evidence of inner retinal cell death, ganglion cell loss, and optic nerve axonal disruption was found in knockout mice.
Conclusions:
- Absence of σR1 results in late-onset retinal dysfunction.
- The findings suggest a role for σR1 in preventing optic neuropathy.
