Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Medical expulsive therapies for ureteric stones: an umbrella review of network meta-analyses with novel evidence grading.

International urology and nephrology·2026
Same author

Integration of L1CAM and β-catenin immunohistochemistry for prognostic risk stratification of endometrial carcinoma: a practical approach for resource-limited settings.

Medical molecular morphology·2026
Same author

Exploring the functional role of XIST in breast cancer from mechanisms to clinical implications.

Discover oncology·2026
Same author

Reply to Letter to the Editor on "Unilateral SLAM: A Simple Novel Technique to Correct Complications of Hypospadias".

Urology·2026
Same author

International multi-stakeholder consensus statement on patient, carer and public involvement to enhance clinical trial integrity.

Accountability in research·2026
Same author

Vestibular compensation: extended review.

Frontiers in neurology·2026

Related Experiment Video

Updated: May 30, 2026

Zebrafish Model of Neuroblastoma Metastasis
05:20

Zebrafish Model of Neuroblastoma Metastasis

Published on: March 14, 2021

Telomerase expression as complementary prognostic factor in neuroblastoma.

Abeer A Bahnassy1, Mohamed Fawzy, Mohamed El-Wakil

  • 1The Departments of Pathology , NCI, Cairo University.

Journal of the Egyptian National Cancer Institute
|August 25, 2011
PubMed
Summary

High telomerase expression in neuroblastoma (NB) patients correlates with n-myc amplification and poor treatment response. This suggests telomerase expression is a potential tool for risk stratification in childhood cancer.

More Related Videos

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
08:34

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

Published on: April 13, 2015

Related Experiment Videos

Last Updated: May 30, 2026

Zebrafish Model of Neuroblastoma Metastasis
05:20

Zebrafish Model of Neuroblastoma Metastasis

Published on: March 14, 2021

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
08:34

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

Published on: April 13, 2015

Area of Science:

  • Oncology
  • Molecular Biology
  • Pediatric Medicine

Background:

  • Neuroblastoma (NB) is a heterogeneous and aggressive childhood cancer.
  • Standard prognostic factors for NB have limitations in risk stratification.
  • New prognostic tools are needed for effective patient management.

Purpose of the Study:

  • To evaluate the prognostic and predictive significance of quantitative telomerase expression in neuroblastoma patients.
  • To correlate telomerase expression with established prognostic markers and treatment outcomes.

Main Methods:

  • Quantitative telomerase expression was assessed using immunohistochemistry in 44 neuroblastoma patients.
  • Results were correlated with standard prognostic factors and n-myc amplification detected by chromogen in situ hybridization (CISH).
  • Patient response to treatment and survival rates were analyzed in relation to telomerase expression levels.

Main Results:

  • High telomerase and n-myc expression were observed in over 50% of patients.
  • A significant association was found between high telomerase expression and n-myc amplification.
  • High telomerase expression correlated with poor treatment response and showed a trend toward lower overall and progression-free survival.

Conclusions:

  • Telomerase expression measured by immunohistochemistry is a potential tool for neuroblastoma risk stratification.
  • Chromogen in situ hybridization (CISH) offers a simple alternative to FISH for identifying abnormal n-myc gene copy number in neuroblastoma.