Related Experiment Video
Updated: May 30, 2026

Minimally Invasive Endoscopic Intracerebral Hemorrhage Evacuation
Published on: October 15, 2021
FloSeal hemostatic matrix use for intraventricular hemorrhage during a neuroendoscopic procedure
A Reeves1, M Muhonen, W Loudon
1Department of Neurosurgery, University of California Irvine, Orange, California 92868, USA. alreeves@uci.edu
Introduction:
Neuroendoscopy is a rapidly growing field, but the risk of intraventricular hemorrhage is signficant. There are few novel ways of obtaining hemostasis for major hemorrhage described in the literature.
Patient:
A 5-year-old boy with a history of intraventricular hemorrhage and multi-cystic hydrocephalus presented with worsening brainstem compression from dilation of a 4 (th) ventricle cyst.
Results:
During endoscopic surgery to fenestrate the cyst, arterial hemorrhage was emergently controlled with the hemostatic agent, FloSeal.
Conclusion:
To the best of the authors' knowledge, this is the first report of a patient with intraoperative intraventricular hemorrhage controlled with FloSeal.
Insights
Neuroendoscopy carries a risk of intraventricular hemorrhage. FloSeal effectively controlled arterial bleeding during a pediatric endoscopic procedure, offering a novel hemostasis option.
Area of Science:
- Neurosurgery
- Minimally Invasive Surgery
- Pediatric Neurosurgery
Background:
- Neuroendoscopy is expanding, yet significant risks like intraventricular hemorrhage persist.
- Limited effective hemostasis methods exist for major intraventricular bleeding during neuroendoscopy.
Observation:
- A pediatric case involved a 5-year-old with hydrocephalus and brainstem compression due to a fourth ventricle cyst.
- Endoscopic cyst fenestration was performed to relieve pressure.
Findings:
- Arterial hemorrhage occurred during the neuroendoscopic procedure.
- The hemostatic agent FloSeal was utilized for emergent bleeding control.
Implications:
- This case represents the first reported use of FloSeal to manage intraoperative intraventricular hemorrhage.
- FloSeal may offer a viable solution for hemostasis in complex neuroendoscopic surgeries.
Related Concept Videos
Hemorrhagic Stroke l: Introduction
Introduction to Hemostasis
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...
Hemorrhagic Stroke ll: Pathophysiology
Anticoagulant Drugs: Low-Molecular-Weight Heparins

