Related Experiment Video
Updated: May 30, 2026

Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors
Published on: July 16, 2012
[Bioinformatics analysis of the structure and function correlated to interferon sensitivity of HCV core protein]
Ling Cheng1, Yan Guo, Guo-hu Hong
1PLA Institute of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
Objective:
To analyze and predict the structure and function correlated to interferon sensitivity of HCV Core protein in different genotypes.
Methods:
Using different bioinformafics software respectively to comparatively analyze and predict the secondary structure, tertiary structure, modification site and main functional motifs of HCV Core protein.
Results:
There were diversities in secondary structure and tertiary structure of different genotypes. HCV Core protein would exist some modification sites about amidation, cAMP, PKC, TYR, and interact with amphiphysin SH3 domain, ERK, PKC.
Conclusion:
Differences in structure and function of HCV Core protein of different genotypes affected interferon sensitivity.
Related Concept Videos
Inhibitors of Viral Protein Synthesis
Structural Protein Function
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to form...
Structural Protein Function
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to form...
Size and Structure of Viral Genomes
Nucleic Acid Structure
DNA Structure
DNA has a double-helix structure. The...
Hepatitis

