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An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
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Chlamydia and chronic arthritis.

John D Carter1, Robert D Inman, Judith Whittum-Hudson

  • 1Division of Rheumatology, Department of Internal Medicine , University of South Florida College of Medicine, Tampa, FL 33612, USA. jocarter@health.usf.edu

Annals of Medicine
|August 26, 2011
PubMed
Summary
This summary is machine-generated.

Certain bacterial infections, like Chlamydia trachomatis, can trigger reactive arthritis. Persistent Chlamydia infections in synovial tissue may drive chronic inflammation, potentially treatable with antimicrobial therapy.

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Area of Science:

  • Microbiology
  • Immunology
  • Rheumatology

Background:

  • Reactive arthritis can be triggered by bacterial infections, most commonly Chlamydia trachomatis.
  • While often self-limiting, Chlamydia-induced reactive arthritis can become chronic in up to 30% of cases.
  • Chlamydiae possess the ability to disseminate and persist in sites like synovial tissue.

Purpose of the Study:

  • To explore the role of persistent Chlamydia infections in the pathogenesis of chronic reactive arthritis.
  • To investigate the efficacy of long-term antimicrobial treatment in managing chronic chlamydial arthritis.

Main Methods:

  • Review of current understanding of chlamydial infections and host-pathogen interactions in arthritis.
  • Analysis of data on long-term combination antimicrobial treatment outcomes.

Main Results:

  • Persistent Chlamydia trachomatis and Chlamydia pneumoniae infections in synovial tissue are implicated in chronic inflammation.
  • Long-term combination antimicrobial treatment can alleviate symptoms and eradicate persistent chlamydial infections.
  • Chronic arthritis may develop even after asymptomatic initial chlamydial infections.

Conclusions:

  • Chlamydiae are a significant cause of chronic arthritis in reactive arthritis.
  • Further research is warranted to determine if these organisms contribute to other forms of chronic arthritis.