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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
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American Trypanosomiasis

Chagas disease, or American trypanosomiasis, is a vector-borne parasitic infection caused by Trypanosoma cruzi, a flagellated protozoan (kinetoplastid) of the family Trypanosomatidae. The disease is endemic in Latin America, although cases are increasingly reported worldwide due to human migration. Transmission most commonly occurs when feces of infected triatomine bugs contaminate bite wounds or mucosal surfaces; additional routes include congenital, transfusional, transplant-related, and oral...
Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

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Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
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Nephrotic Syndrome II : Assessment and Medical Management

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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
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Systemic lupus erythematosus in Hispanics.

Yemil Atisha-Fregoso1, Juan Jakez-Ocampo, Luis Llorente

  • 1Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Autoimmunity
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PubMed
Summary

Systemic lupus erythematosus (SLE) disproportionately affects Hispanic patients, with higher rates of kidney complications and mortality. Further research is needed to understand genetic and molecular factors contributing to these disparities in SLE.

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Area of Science:

  • Immunology
  • Genetics
  • Public Health

Background:

  • Systemic lupus erythematosus (SLE) is a severe autoimmune disease with known ethnic variations in clinical presentation.
  • Hispanic populations have been underrepresented in SLE research, leading to a lack of understanding of disease characteristics in this group.
  • Existing data suggest heterogeneity within the Hispanic SLE cohort, with potential genetic influences on disease susceptibility and protection.

Purpose of the Study:

  • To investigate the clinical and molecular characteristics of systemic lupus erythematosus in the Hispanic population.
  • To identify potential genetic factors contributing to SLE susceptibility or protection in Hispanics.
  • To understand the disparities in SLE outcomes, including renal complications and mortality, within this ethnic group.

Main Methods:

  • Review of available clinical and genetic data concerning SLE in Hispanic patients.
  • Analysis of documented clinical manifestations and mortality rates.
  • Identification of preliminary genetic mutations associated with SLE in the studied cohort.

Main Results:

  • Hispanic SLE patients exhibit significant heterogeneity.
  • Certain genetic mutations may influence disease susceptibility or protection in this population.
  • Higher rates of renal complications and mortality are observed in Hispanic SLE patients compared to other ethnic groups.
  • Socio-economic factors and healthcare access may contribute to increased mortality.

Conclusions:

  • Hispanic populations show distinct clinical patterns in SLE, including increased renal involvement and mortality.
  • Sociological factors likely play a role, but genetic and molecular mechanisms require further investigation.
  • More research is essential to elucidate the genetic and molecular underpinnings of SLE disparities in Hispanic patients.