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Expression, Purification, and Antimicrobial Activity of S100A12

Expression, Purification, and Antimicrobial Activity of S100A12

Published on: May 13, 2017

Reference values for venous and capillary S100B in children.

Ramona Astrand¹, Bertil Romner, Jan Lanke

¹Department of Neurosurgery, Lund University, Lund, Sweden. raastrand@gmail.com

Clinica Chimica Acta; International Journal of Clinical Chemistry

|August 26, 2011

Summary

This summary is machine-generated.

This study establishes reference values for serum protein S100B in children using both venous and capillary blood. These findings aid in evaluating S100B for managing pediatric mild head injury and reducing unnecessary CT scans.

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Published on: August 19, 2020

Area of Science:

Biochemistry
Pediatric Medicine
Neurology

Background:

Current pediatric mild head injury (MHI) guidelines often lead to unnecessary computed tomography (CT) scans and hospital admissions.
Serum protein S100B shows promise in adults for reducing CT use in mild head injury.
Capillary blood sampling is a common alternative to venous sampling in children.

Purpose of the Study:

To establish reference values for serum protein S100B in healthy children.
To compare S100B levels between venous and capillary blood samples.
To provide data supporting the potential use of S100B in pediatric mild head injury management.

Main Methods:

Prospective study of neurologically healthy children aged 1-16 undergoing minor surgery.
Venous blood samples collected pre-sedation; venous and capillary samples collected post-sedation.
Analysis of serum protein S100B levels in relation to age and gender.

Main Results:

Serum S100B levels were higher in younger children (aged 1-2) compared to older children (aged 3-14).
Reference levels established: venous 0.15 μg/L and capillary 0.37 μg/L for children aged 3-14.
A gender difference in capillary S100B was observed in the youngest age groups.

Conclusions:

Reference values for venous and capillary S100B in healthy children are presented.
These values are crucial for future research on pediatric head injury biomarkers.
S100B may help optimize diagnostic pathways for mild head injury in pediatric populations.