Arterial remodeling and atherosclerosis: miRNAs involvement

Area of Science:

• Cardiovascular Biology
• Molecular Genetics
• Genomics

Background:

• Cardiometabolic diseases (CMD), including atherosclerosis, diabetes, and hypertension, are leading causes of mortality and disability.
• Despite advancements in lifestyle programs and therapies, a significant residual risk of CMD events persists.
• Genetics and genomics offer new avenues to understand CMD, identify at-risk individuals, and discover novel therapeutic targets.

Purpose of the Study:

• To review recent advancements in understanding the role of microRNAs (miRNAs) in arterial remodeling and atherosclerosis.
• To highlight the potential of miRNAs as therapeutic targets for cardiometabolic diseases.

Main Methods:

• Review of recent scientific literature on microRNAs, arterial remodeling, and atherosclerosis.
• Bioinformatics analysis predicting miRNA targets and their biological roles.

Main Results:

• MicroRNAs (miRNAs) are short, non-coding RNAs that regulate protein expression.
• miRNAs are predicted to influence numerous biological pathways, including those in the cardiovascular system.
• Emerging evidence underscores the fundamental importance of miRNAs in vascular biology and their involvement in atherosclerosis.

Conclusions:

• MicroRNAs play a critical role in arterial remodeling and the development of atherosclerosis.
• Further research into miRNAs may lead to novel therapeutic strategies for managing cardiometabolic diseases and reducing residual risk.