Combinations of insulin and oral hypoglycemic agents in diabetes mellitus type 2

Insulin therapy is considered to be the most effective therapy for the reduction of high glucose levels. In patients who cannot be regulated with the combination of oral hypoglycemic agents, insulin should be administrated. The first step is the combination of insulin together with the already administrated oral hypoglycemic agents. The fear for hypoglycemia, the refusal and weakness that patients face when dealing with insulin, constitute reasons for many doctors to deal with insulin therapy in a more skeptical way. As a result, the initiation of insulin therapy is delayed for those patients who need it for hyperglycemia adjustments. This article provides useful practical instructions for initiating insulin therapy.