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Updated: Aug 13, 2026

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) Procedure
Published on: August 14, 2017
[Is a pharmacological treatment of liver cirrhosis possible?]
1Institut für Klinische Pharmakologie, Universität Bern.
Abstract:
Loss of hepatic function is the limiting factor in survival of patients with cirrhosis. Fibrogenesis, cytolysis/necrosis and sinusoidal capillarization, altered composition of biomembranes, and hyporegeneration are identified as major factors in loss of hepatic function. Fibrogenesis has been successfully treated with colchicine. Cytolysis/necrosis in autoimmune hepatitis has for years been treated successfully with steroids: in postviral chronic hepatitis the interferons are showing high promise. Treatment of the other factors is the subject of intensive basic and clinical research.
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