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Related Concept Videos

Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
Inflammation01:38

Inflammation

Overview
Acute Inflammation II: Cellular Phase01:26

Acute Inflammation II: Cellular Phase

The cellular phase of acute inflammation is a tightly orchestrated sequence of events that recruits leukocytes, primarily neutrophils, to sites of tissue injury or infection. Following the initial vascular changes, this phase ensures effective immune cell migration, activation, and function at the affected site to eliminate pathogens and initiate tissue repair.Leukocyte Recruitment CascadeLeukocyte recruitment happens in four steps: margination, adhesion, transmigration, and chemotaxis. Reduced...

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Related Experiment Video

Updated: May 29, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Inflammatory response in acute chorioamnionitis.

Raymond W Redline1

  • 1Pediatric and Perinatal Pathology, Case Western Reserve University School of Medicine, OH 44106, USA. raymondw.redline@UHhospitals.org

Seminars in Fetal & Neonatal Medicine
|August 26, 2011
PubMed
Summary
This summary is machine-generated.

Histologic chorioamnionitis, an inflammation of the placental membranes, is a primary cause of premature birth. This review focuses on the maternal and fetal inflammatory response within the placenta, examining its origins and pathological manifestations.

Related Experiment Videos

Last Updated: May 29, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Area of Science:

  • Obstetrics and Gynecology
  • Perinatal Medicine
  • Pathology

Background:

  • Acute chorioamnionitis is a leading cause of preterm birth and associated neonatal complications.
  • Surrogate markers for in-utero inflammation are widely studied, but direct assessment remains crucial.
  • Histopathology is the primary method for diagnosing chorioamnionitis in placental tissues.

Purpose of the Study:

  • To review the maternal and fetal inflammatory response to organisms within the placental membranes.
  • To characterize the spectrum of pathologic lesions in placentas with membrane infection.
  • To explore the origin and spread of the eliciting antigen and placental immunity.

Main Methods:

  • Review of existing literature on chorioamnionitis and placental pathology.
  • Analysis of the inflammatory response to microbial invasion in placental membranes.
  • Characterization of pathological findings in infected placentas.

Main Results:

  • Histologic chorioamnionitis signifies inflammation within the chorioamnion, directly linked to adverse pregnancy outcomes.
  • Understanding the inflammatory pathways and immune responses is key to managing chorioamnionitis.
  • Pathologic lesions provide direct evidence of infection and inflammation in the placental membranes.

Conclusions:

  • Histopathology is essential for diagnosing chorioamnionitis and understanding its impact on pregnancy.
  • Further research into placental immunity and inflammatory responses can inform clinical management.
  • Direct assessment of placental inflammation is critical for addressing complications of premature birth.