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Updated: May 29, 2026

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
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Lipoma or liposarcoma? A cautionary case report.

A P Jones1, C J Lewis, P Dildey

  • 1Department of Plastic Surgery, Royal Victoria Infirmary, Queen Victoria Road, Newcastle-upon-Tyne, NE1 4LP, UK.

Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS
|August 26, 2011
PubMed
Summary

MERRF syndrome patients with cervical lipomas require careful evaluation. Imaging is crucial to distinguish benign lipomas from liposarcomas, preventing misdiagnosis and ensuring appropriate treatment.

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Area of Science:

  • Mitochondrial encephalomyopathies
  • Neurology
  • Oncology

Background:

  • MERRF syndrome (myoclonic epilepsy with ragged-red fibres) is a mitochondrial disorder.
  • Patients often develop large cervical lipomas requiring surgical removal.
  • Differentiating benign lipomas from malignant liposarcomas is clinically significant.

Observation:

  • A case presented with multiple large cervical lipomas.
  • Pre-operative clinical and radiological assessments suggested benign lipomas.
  • Post-excision histopathology revealed a lipoma-like liposarcoma.

Findings:

  • The case highlights the potential for sarcomatous transformation in lipomas.
  • Radiological imaging can be misleading in differentiating lipomas from liposarcomas.

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  • Histopathological examination is definitive for diagnosis.

    • Implications:

    • Emphasizes the need for high suspicion and thorough evaluation of cervical lipomas in MERRF syndrome.
    • Underscores the limitations of imaging in distinguishing benign from malignant fatty tumors.
    • Highlights the importance of surgical excision and histopathological analysis for accurate diagnosis and treatment planning.