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Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...

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Related Experiment Video

Updated: May 29, 2026

Measuring Psoriasis Severity at Home
02:28

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Endothelial dysfunction in psoriasis patients: cross-sectional case-control study.

Clara De Simone1, Angela Di Giorgio, Teresa Sisto

  • 1Department of Dermatology, Catholic University of the Sacred Heart, Largo Gemelli 8, 00168 Rome, Italy.

European Journal of Dermatology : EJD
|August 26, 2011
PubMed
Summary
This summary is machine-generated.

Psoriasis patients show impaired endothelial function, indicating early signs of atherosclerosis. This suggests a higher cardiovascular risk independent of traditional factors.

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Last Updated: May 29, 2026

Measuring Psoriasis Severity at Home
02:28

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Area of Science:

  • Dermatology
  • Cardiology
  • Immunology

Background:

  • Psoriasis is an inflammatory skin disease linked to increased cardiovascular disease (CVD) risk.
  • Psoriasis patients face higher atherothrombotic disease risk, irrespective of conventional CVD risk factors.
  • Inflammation in psoriasis contributes to endothelial dysfunction (ED), a marker of subclinical atherosclerosis.

Purpose of the Study:

  • To non-invasively assess endothelial dysfunction (ED) in psoriasis patients.
  • To evaluate brachial artery flow-mediated dilation (FMD) and nitroglycerin-induced dilation (NID) in psoriasis.
  • To determine if psoriasis is associated with subclinical atherosclerosis.

Main Methods:

  • Utilized ultrasonography to measure brachial artery FMD and NID.
  • Included 32 psoriasis patients and 31 healthy controls.
  • Excluded patients with diabetes, renal failure, cancer, major CVD, cerebrovascular disease, or psoriatic arthritis.

Main Results:

  • Psoriasis patients demonstrated significantly lower FMD compared to controls.
  • No significant difference in NID was observed between psoriasis patients and controls.
  • Results indicate impaired endothelial function in psoriasis.

Conclusions:

  • Psoriasis is associated with impaired endothelial function.
  • Psoriasis patients may experience subclinical atherosclerosis.
  • Early detection of ED in psoriasis is crucial for cardiovascular risk assessment.