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Related Concept Videos

Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...

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Updated: May 29, 2026

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay
07:40

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay

Published on: April 28, 2022

Scars.

Mohamed L Elsaie, Sonal Choudhary, Michael McLeod

    Current Problems in Dermatology
    |August 26, 2011
    PubMed
    Summary
    This summary is machine-generated.

    Laser treatments offer variable outcomes for scar improvement. The 585 nm pulsed dye laser is ideal for hypertrophic scars and keloids, while ablative lasers like CO2 and Er:YAG excel at treating atrophic scars.

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    Area of Science:

    • Dermatology
    • Medical Aesthetics
    • Laser Therapy

    Background:

    • Scars are broadly classified into atrophic, hypertrophic, and keloid types.
    • Various laser modalities have been explored for scar revision with inconsistent results.
    • Current dermatological practice employs multiple laser systems for scar treatment.

    Purpose of the Study:

    • To review the efficacy of different lasers in improving scar appearance.
    • To discuss the mechanisms and applications of various laser treatments for scars.
    • To provide an overview of current laser-based scar management strategies.

    Main Methods:

    • Review of existing literature on laser scar treatment.
    • Discussion of specific laser types including pulsed dye, CO2, and Er:YAG lasers.
    • Comparison of ablative and non-ablative laser approaches for scar revision.

    Main Results:

    • The 585 nm pulsed dye laser is recognized as the gold standard for hypertrophic scars and keloids.
    • Ablative lasers (CO2, Er:YAG) are most effective for atrophic scars.
    • Non-ablative lasers offer reduced downtime with satisfactory outcomes.

    Conclusions:

    • Different laser types are indicated for specific scar morphologies.
    • Pulsed dye, ablative, and non-ablative lasers represent key tools in scar improvement.
    • Laser therapy continues to evolve, offering diverse options for managing various scar types.