Related Experiment Video
Updated: May 29, 2026
11:27
Analysis of SCAP N-glycosylation and Trafficking in Human Cells
Published on: November 8, 2016
ESCRT proteins: Double-edged regulators of cellular signaling
Chun Tu1, Gulzar Ahmad, Bhopal Mohapatra
1Eppley Institute for Research in Cancer and Allied Diseases and UNMC-Eppley Cancer Center; Omaha, NE USA.
Bioarchitecture
|August 26, 2011
Summary
The ESCRT pathway, involved in receptor sorting, also promotes cancer cell signaling and invasion. This study reveals ESCRT proteins
Area of Science:
- Cell Biology
- Molecular Biology
- Cancer Research
Background:
- The ESCRT pathway typically sorts ubiquitinated receptors to lysosomes, attenuating cell surface signaling.
- However, ESCRT proteins like Tsg101 and Hrs are overexpressed in cancers, suggesting pro-tumor roles.
- The mechanisms behind ESCRT's positive roles in signal transduction remain unclear.
Purpose of the Study:
- To elucidate the mechanisms underlying the positive contributions of the ESCRT pathway to surface receptor signaling.
- To investigate the role of ESCRT components in Src-mediated cell migration and invasion.
Main Methods:
- Investigated the role of Tsg101 and Vps4 in the translocation of active Src.
- Examined the localization of Src in endosomes, focal adhesions, and invadopodia.
Main Results:
- Tsg101 and Vps4 were found to be essential for the translocation of active Src from endosomes to focal adhesions and invadopodia.
- These findings reveal a role for the ESCRT pathway in promoting Src-mediated cell migration and invasion.
Conclusions:
- The ESCRT pathway plays a crucial role in promoting Src-mediated cell migration and invasion.
- ESCRT proteins may also be involved in recycling endocytic cargo, in addition to lysosomal targeting, explaining their positive roles in signal transduction.
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