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Kikuchi-Fujimoto disease mimicking malignant lymphoma
G A Chamulak1, R K Brynes, B N Nathwani
1Department of Pathology, Los Angeles County, University of Southern California Medical Center.
The American Journal of Surgical Pathology
|June 1, 1990
Summary
Kikuchi-Fujimoto disease, a benign condition, is often misdiagnosed as lymphoma. This study details key features distinguishing it from lymphoma, aiding accurate diagnosis of this rare lymphadenitis.
Area of Science:
- Pathology
- Hematopathology
- Oncology
Background:
- Histiocytic necrotizing lymphadenitis, now known as Kikuchi-Fujimoto disease, is a rare benign condition.
- It can be morphologically mistaken for malignant lymphoma, leading to diagnostic challenges.
Purpose of the Study:
- To highlight the distinct morphologic features of Kikuchi-Fujimoto disease.
- To differentiate it from malignant lymphoma based on pathological findings.
Main Methods:
- Analysis of morphologic features in 10 selected cases of histiocytic necrotizing lymphadenitis.
- Identification of features mimicking lymphoma and those aiding accurate diagnosis.
Main Results:
- Distinctive features include pale pathologic areas, preserved sinuses, histiocyte mottling, absence of overt necrosis, atypical histiocytes resembling cleaved cells, nuclear debris, plasmacytoid T cells, and absence of inflammation.
- The presence of these features supports the renaming to Kikuchi-Fujimoto disease.
Conclusions:
- Accurate diagnosis of Kikuchi-Fujimoto disease relies on recognizing specific histopathologic features.
- Distinguishing Kikuchi-Fujimoto disease from lymphoma is crucial for appropriate patient management.