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Insulin allergy: re-evaluation after two decades.

R Patterson1, M Roberts, L C Grammer

  • 1Department of Medicine, Northwestern University Medical School, Chicago, Illinois.

Annals of Allergy
|May 1, 1990
PubMed
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Immunoglobulin E (IgE)-mediated insulin allergy, specifically Prausnitz-Kustner reactivity, remained stable over 15 years. However, overall IgE-mediated insulin allergy appears to be declining in prevalence.

Area of Science:

  • Immunology
  • Allergy
  • Endocrinology

Background:

  • Insulin allergy is an adverse reaction to insulin therapy.
  • Immunoglobulin E (IgE)-mediated reactions are a common type of insulin allergy.
  • Longitudinal studies on the persistence of IgE-mediated insulin allergy are limited.

Purpose of the Study:

  • To reevaluate the persistence of IgE-mediated insulin allergy.
  • To assess changes in antibody specificity and reactivity over time.
  • To determine if IgE-mediated insulin allergy is declining.

Main Methods:

  • Sera from patients with IgE-mediated insulin allergy, collected 16-21 years ago, were reevaluated.
  • Antibody specificity for human and bovine insulin was assessed.
  • Prausnitz-Kustner reactivity was reevaluated after 15 years.

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Main Results:

  • All tested antibodies demonstrated specificity for both human and bovine insulin.
  • IgE antibody levels and cutaneous reactivity remained unchanged after 15 years.
  • Despite stable individual reactivity, the overall prevalence of IgE-mediated insulin allergy appears to be decreasing.

Conclusions:

  • IgE-mediated insulin allergy, characterized by specific antibodies and reactivity, can be persistent over long periods.
  • The declining prevalence suggests a potential decrease in the incidence or diagnosis of this condition.
  • Further research is needed to understand the factors contributing to the decline in IgE-mediated insulin allergy.