Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Aneurysm III: Interprofessional Care

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...

Aneurysm I: Introduction

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

GP130 Antagonism Enhances Porcine RV Function.

Circulation research·2025

Same author

Histological assessment of a novel restorative coronary artery bypass graft in a chronic ovine model.

Frontiers in bioengineering and biotechnology·2025

Same author

Glycoprotein 130 Antagonism Counteracts Metabolic and Inflammatory Alterations to Enhance Right Ventricle Function in Pulmonary Artery Banded Pigs.

bioRxiv : the preprint server for biology·2025

Same author

Norepinephrine Infusion and the Central Venous Waveform in a Porcine Model of Endotoxemic Hypotension with Resuscitation: A Large Animal Study.

Journal of investigative surgery : the official journal of the Academy of Surgical Research·2025

Same author

Challenges in the Development and Evaluation of Pediatric Heart Valve Technologies.

The Annals of thoracic surgery·2024

Same author

Non-immune factors cause prolonged myofibroblast phenotype in implanted synthetic heart valve scaffolds.

Applied materials today·2024

Search research articles

Related Experiment Video

Updated: May 29, 2026

Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Published on: March 28, 2025

Internal aortic annuloplasty: a novel technique.

John L Schomburg¹, Matthew T Lahti, George R Ruth

¹Medical School, University of Minnesota, Minneapolis, USA.

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research

|August 27, 2011

Summary

A novel aortic annulus repair device was tested in sheep, establishing a reproducible surgical technique for preclinical safety assessments. The study demonstrated feasibility with one early mortality and mild aortic insufficiency in survivors.

More Related Videos

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Published on: December 11, 2017

Related Experiment Videos

Last Updated: May 29, 2026

Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Published on: March 28, 2025

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Published on: December 11, 2017

Area of Science:

Cardiovascular Surgery
Biomedical Engineering
Preclinical Research

Background:

Developing novel devices for aortic annulus repair is crucial for treating valvular heart disease.
Preclinical models are essential for evaluating the safety and biocompatibility of new medical devices.

Purpose of the Study:

To establish an experimental model for assessing a new intra-annular internal aortic annulus repair device.
To define a reproducible surgical technique for the device's preclinical evaluation.

Main Methods:

An aortic annulus repair device from HAART Inc. was implanted in adult sheep (n=6) using standard surgical procedures.
Animals were monitored until elective sacrifice at 30 or 60 days post-implantation.

Main Results:

One sheep (16.7%) experienced early mortality due to a surgical complication.
The remaining five sheep were stable until sacrifice.
Echocardiography revealed mild-to-moderate aortic insufficiency in all surviving animals.

Conclusions:

A reproducible surgical technique was developed in a suitable animal model for internal aortic annulus repair devices.
The feasibility of preclinical assessment for this device was demonstrated.
Further evaluation is needed to understand the causes of observed aortic insufficiency.