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Updated: May 29, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
Development and prevention of morphologic and ultrastructural changes in uremia-induced hyperplastic parathyroid
Kazuhiro Shiizaki1, Ikuji Hatamura, Masao Mato
1Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan. shiizaki@jichi.ac.jp
Abstract:
The detailed ultrastructural changes of uremia-induced hyperplastic parathyroid gland and the effects of current medical treatments for secondary hyperparathyroidism were investigated. Marked enlargement of parathyroid cell with accumulation of mitochondria and lipids and a significant increase in the thickness of the pericapillary area with increased fibrosis and appearance of fibroblast like cells were noted in the hyperplastic gland caused by uremia and phosphate retention. These ultrastructural changes and biochemical findings indicating hyperparathyroidism were significantly suppressed by all of the treatment using phosphate restriction, calcitriol, and cinacalcet. The characteristic ultrastructural changes, including the morphologic evidence of nodule formation, were indicated.
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