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Synthesis of (-)-arctigenin derivatives and their anticancer activity
Chen Gui-Rong1, Cai Li-Ping, Dou De-Qiang
1College of pharmacy, Liaoning University of Traditional Chinese Medicine, 77 Life one Road, DD port, Dalian 116600, China.
Natural Product Research
|August 27, 2011
Abstract:
The natural dibenzylbutyrolactone type lignanolide (-)-arctigenin, which was prepared from fructus arctii, showed obvious anticancer activity. The synthesis of four new (-)-arctigenin derivatives and their anticancer bioactivities were examined. The structures of the four new synthetic derivatives were elucidated.