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Bacterial L-arabinose isomerases: industrial application for D-tagatose production
Samira Boudebbouze1, Emmanuelle Maguin, Moez Rhimi
1Laboratory for Biocrystallography and Structural Biology of Therapeutical Targets, BMSSI- Institut de Biologie et Chimie des Proteines, UMR 5086-CNRS/Universite de Lyon, FR3302 BioSciences Gerland - Lyon Sud, F-69367 Lyon cedex 07, France.
Abstract:
D-tagatose is a natural monosaccharide with a low caloric value and has an anti-hyperglycemiant effect. This hexose has potential applications both in pharmaceutical and agro-food industries. However, the use of D-tagatose remains limited by its production cost. Many production procedures including chemical and biological processes were developed and patented. The most profitable production way is based on the use of L-arabinose isomerase which allows the manufacture of D-tagatose with an attractive rate. Future developments are focused on the generation of L-arabinose isomerases having biochemical properties satisfying the industrial applications. This report provides a brief review of the most recent patents that have been published relating to this area.
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In aerobic organisms, pyruvate is metabolized via the citric acid cycle to produce reduced coenzymes NADH and FADH2. These coenzymes are then oxidized in the electron transport chain to produce ATP and, in the process, regenerate the NAD+ and FAD. As seen in some cell types and organisms, fermentation...

