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Related Concept Videos

Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved DNA...

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Effective Rapid Blood Perfusion in Xenopus
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A multi-organ transcriptome resource for the Burmese Python (Python molurus bivittatus).

Todd A Castoe1, Samuel E Fox, Ap Jason de Koning

  • 1Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO 80045 USA. todd.castoe@ucdenver.edu.

BMC Research Notes
|August 27, 2011
PubMed
Summary
This summary is machine-generated.

Researchers created a valuable genomic resource for Burmese pythons by assembling and annotating thousands of transcripts from heart and liver tissues. This transcriptome data will advance studies on snake physiology and evolution.

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Area of Science:

  • Comparative genomics
  • Physiological adaptations
  • Vertebrate research

Background:

  • Snakes exhibit extreme adaptations in development, metabolism, and physiology.
  • Genomic resources for snakes are limited, hindering research.
  • The Burmese python is a key model for studying metabolic fluctuations and organ remodeling.

Purpose of the Study:

  • To establish a foundational genomic resource for Burmese python research.
  • To assemble and annotate a reference transcriptome from python heart and liver tissues.

Main Methods:

  • Utilized 454-FLX sequencing to generate nearly 1 million sequence reads.
  • Assembled sequence data into 37,245 contigs.
  • Annotated 13,286 contigs by comparing them to known gene sets and Genbank sequences.

Main Results:

  • Generated a transcriptome assembly of 13,409,006 bp.
  • Identified and annotated over 13,000 gene-containing contigs.
  • Made raw data, assembly, and annotations publicly available.

Conclusions:

  • This transcriptome serves as a significant genomic resource for Burmese pythons.
  • Facilitates future research on snake evolutionary and physiological systems.
  • Supports the use of snakes as models for extreme biological adaptations.