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Investigating striatal function through cell-type-specific manipulations.

A C Kreitzer1, J D Berke

  • 1Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA. akreitzer@gladstone.ucsf.edu

Neuroscience
|August 27, 2011
PubMed
Summary

Researchers are uncovering the specific functions of striatal neurons in motivated behavior. New in vivo methods allow direct testing of how different striatal cell types influence actions.

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Area of Science:

  • Neuroscience
  • Behavioral Neuroscience

Background:

  • The striatum receives input from the cortex, thalamus, and midbrain.
  • It plays a key role in motivated behavior through its outputs to basal ganglia nuclei.
  • Understanding distinct striatal neuron subpopulations' functions is challenging.

Purpose of the Study:

  • To investigate the causal roles of specific striatal neuron subpopulations in motivated behavior.
  • To leverage novel in vivo methodologies for perturbing neuronal activity and signaling.

Main Methods:

  • Application of new in vivo techniques.
  • Perturbation of activity and signaling in distinct striatal cell types.

Main Results:

  • Emerging data from new methodologies are beginning to elucidate functional roles.
  • Direct tests of causal roles in behavior are now feasible.

Conclusions:

  • Novel in vivo methods are enabling direct investigation of striatal neuron function.
  • These approaches are crucial for understanding the neural basis of motivated behavior.