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Stereotaxic Surgery for Genetic Manipulation in Striatal Cells of Neonatal Mouse Brains

Stereotaxic Surgery for Genetic Manipulation in Striatal Cells of Neonatal Mouse Brains

Published on: July 10, 2018

Investigating striatal function through cell-type-specific manipulations.

A C Kreitzer¹, J D Berke

¹Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA. akreitzer@gladstone.ucsf.edu

|August 27, 2011

Summary

This summary is machine-generated.

Researchers are uncovering the specific functions of striatal neurons in motivated behavior. New in vivo methods allow direct testing of how different striatal cell types influence actions.

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Area of Science:

Neuroscience
Behavioral Neuroscience

Background:

The striatum receives input from the cortex, thalamus, and midbrain.
It plays a key role in motivated behavior through its outputs to basal ganglia nuclei.
Understanding distinct striatal neuron subpopulations' functions is challenging.

Purpose of the Study:

To investigate the causal roles of specific striatal neuron subpopulations in motivated behavior.
To leverage novel in vivo methodologies for perturbing neuronal activity and signaling.

Main Methods:

Application of new in vivo techniques.
Perturbation of activity and signaling in distinct striatal cell types.

Main Results:

Emerging data from new methodologies are beginning to elucidate functional roles.
Direct tests of causal roles in behavior are now feasible.

Conclusions:

Novel in vivo methods are enabling direct investigation of striatal neuron function.
These approaches are crucial for understanding the neural basis of motivated behavior.