Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Physiological changes in ageing skin.

D Cerimele1, L Celleno, F Serri

  • 1Department of Dermatology, Catholic University, Rome, Italy.

The British Journal of Dermatology
|April 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Artificial intelligence and future perspectives in Forensic Medicine: a systematic review.

La Clinica terapeutica·2024
Same author

Clinical and Biological Aspects of Skin Aging.

Indian journal of dermatology and venereology·2017
Same author

Paradoxical psoriasis in a large cohort of patients with inflammatory bowel disease receiving treatment with anti-TNF alpha: 5-year follow-up study.

Alimentary pharmacology & therapeutics·2015
Same author

Development of psoriasis scalp with alopecia during treatment of Crohn's disease with infliximab and rapid response to both diseases to ustekinumab.

European review for medical and pharmacological sciences·2013
Same author

Photobiology, photodermatology and sunscreens: a comprehensive overview. Part 1: damage from acute and chronic solar exposure.

Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia·2013
Same author

Photobiology, photodermatology and sunscreens: a comprehensive overview. Part 2: topical and systemic photoprotection.

Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia·2013
Same journal

Comment on 'Incidence and Mortality of Mucous Membrane Pemphigoid in France': reply from authors.

The British journal of dermatology·2026
Same journal

Randomised Controlled Feasibility Trial of an Intervention to Reduce Infant Bathing.

The British journal of dermatology·2026
Same journal

Dupilumab treatment restores skin nerve fibre density in patients with moderate-to-severe atopic dermatitis: results from DIFFERENSTAD, an open-label exploratory study.

The British journal of dermatology·2026
Same journal

Mee's Lines.

The British journal of dermatology·2026
Same journal

Geographic diversity in top dermatology journal editorial boards.

The British journal of dermatology·2026
Same journal

Molecular heterogeneity in systemic sclerosis skin: insights from single-cell and spatial omics, and implications for disease stratification and cutaneous assessment.

The British journal of dermatology·2026
See all related articles

Skin aging significantly reduces its protective and regulatory functions, with many capabilities decreasing by over 50%. This impacts barrier function, cell turnover, and immune response, making skin more vulnerable.

Area of Science:

  • Dermatology
  • Gerontology
  • Immunology

Background:

  • The skin performs numerous vital functions including protection, thermoregulation, and immune response.
  • Aging leads to structural and physiological changes that impair these essential skin functions.

Purpose of the Study:

  • To outline the principal functions of the skin.
  • To describe the structural and physiological changes associated with skin aging.
  • To explain how these age-related changes affect skin function.

Main Methods:

  • Review of established physiological and structural changes in aging skin.
  • Analysis of the impact of these changes on skin functions.
  • Consideration of environmental factors accelerating skin aging.

Related Experiment Videos

Main Results:

  • Skin functions like protection, excretion, and immune response are reduced with age, some by 50-60%.
  • Physiological changes include impaired barrier function, reduced cell turnover, fewer keratinocytes and fibroblasts, and a diminished vascular network.
  • Age-related changes lead to skin atrophy, reduced hair and nail growth, decreased vitamin D synthesis, and a weaker immune response.

Conclusions:

  • Skin aging results in a significant decline in multiple skin functions.
  • Environmental factors, especially sun exposure, exacerbate skin aging and increase cancer risk.
  • Understanding these changes is crucial for managing age-related skin conditions and prevention.