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Updated: May 29, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Hydrazidomycins, cytotoxic alkylhydrazides from Streptomycesatratus
Nico Ueberschaar1, Basile Le Sage Tchize Ndejouong, Ling Ding
1Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstr, 11a, D-07745 Jena, Germany.
Abstract:
Three unusual alkyhydrazide natural products, named hydrazidomycin A (1), B (2) and C (3), were isolated from the chloroform extract of a Streptomycesatratus culture, and their structures were elucidated by MS and NMR techniques. Hydrazidomycins A-C exhibited moderate to strong cytotoxic activities in a panel of 42 cell lines, with hydrazidomycin A being the most potent compound (mean IC(50)=0.37 μM).
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