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[Endometrial microvessel density for assessing endometrial receptivity during the peri-implantation period]
Qiu-hua Li1, Min Yu, Lei-ning Chen
1Department of Obstetrics and Gynecology, Southern Medical University, Guangzhou, China. liqiuhua1320@yahoo.com.cn
Objective:
To evaluate the value of endometrial microvessel density (MVD) in assessing the endometrial receptivity during the peri-implantation period.
Methods:
A total of 104 patients undergoing in vitro fertilization and embryo transfer (IVF-ET) treatment were analyzed retrospectively. The subjects were divided into clinical pregnancy group (50 cases) and nonpregnant group (54 cases) according to the IVF-ET outcome. Endometrial tissues were collected 7 days after the natural ovulation prior to IVF-ET for measurement of the endometrial MVD using electron microscopy, which was analyzed in relation to the clinical outcome of the treatment.
Results:
The endometrial MVD was significantly higher in the clinical pregnancy group than in the nonpregnant group [(4.12∓1.84)% vs (3.46∓1.26)%, t=-2.127, P=0.036). ROC curve analysis showed that the MVD had an area under the curve slightly over 0.5 (0.598) for predicting clinical pregnancy, suggesting a poor specificity in predicting the clinical outcome of the treatment.
Conclusion:
In IVF-ET cycles, the endometrial MVD during the peri-implantation period is helpful for assessing the endometrial receptivity, but the specificity remains low.
