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Published on: June 5, 2010
Treatment of sydenham chorea with intravenous immunoglobulin
Kathleen Walker1, Anita Brink, John Lawrenson
1Rheumatic Fever Clinic, Department of Cardiology, Red Cross Children's Hospital, School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa. buley@iafrica.com
Abstract:
Sydenham chorea is a post-streptococcal, autoimmune, neuropsychiatric, movement disorder. There is no effective treatment. In a randomized study, comparison was made of the outcomes of 10 children treated with standard management alone compared to 10 who received additional intravenous immunoglobulin. The outcomes were assessed using a clinical rating scale, brain single-photon emission computed tomography, and the duration of symptomatic treatment. All three outcome measurement tools found improved outcomes in the group that received intravenous immunoglobulin.
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