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Related Concept Videos

Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...

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Related Experiment Video

Updated: May 29, 2026

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography
10:33

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography

Published on: February 3, 2014

Obesity and right ventricular structure and function: the MESA-Right Ventricle Study.

Harjit Chahal1, Robyn L McClelland2, Harikrishna Tandri3

  • 1Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD.

Chest
|August 27, 2011
PubMed
Summary

Obesity is linked to changes in the right ventricle (RV) structure and function. Overweight and obese individuals show increased RV mass and volume, and reduced RV ejection fraction compared to lean individuals.

More Related Videos

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

Related Experiment Videos

Last Updated: May 29, 2026

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography
10:33

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography

Published on: February 3, 2014

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Obesity Medicine

Background:

  • The impact of obesity on right ventricular (RV) morphology and function remains under-investigated.
  • Existing research has not extensively explored the association between obesity and RV structure in diverse populations.

Purpose of the Study:

  • To investigate the relationship between obesity and right ventricular (RV) structure and function.
  • To analyze RV morphology and function in a large, multiethnic cohort across different body mass index (BMI) categories.

Main Methods:

  • Utilized cardiac MRI data from the Multi-Ethnic Study of Atherosclerosis (MESA) Right Ventricle Study.
  • Assessed RV mass and volumes in 4,127 participants aged 45-84 years, categorized by BMI: lean (≤24.9 kg/m²), overweight (25-29.9 kg/m²), and obese (≥30 kg/m²).

Main Results:

  • Obese and overweight individuals exhibited significantly greater RV mass, end-diastolic volume, and stroke volume compared to lean individuals.
  • A lower RV ejection fraction was observed in overweight and obese participants.
  • These associations remained significant after adjusting for demographics, cardiovascular risk factors, and left ventricular (LV) parameters.

Conclusions:

  • Overweight and obesity are independently associated with altered RV morphology and function.
  • Potential mechanisms include increased RV afterload, elevated blood volume, hormonal influences, or direct myocardial effects of obesity.
  • Findings highlight the cardiovascular impact of excess weight on the right ventricle.