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Updated: May 29, 2026

Functional Characterization of Endogenously Expressed Human RYR1 Variants
Published on: June 9, 2021
Elevated YB-1 expression is a new unfavorable prognostic factor in non-Hodgkin's lymphomas
Katarzyna Szczuraszek1, Agnieszka Halon, Verena Materna
1Department of Histology and Embryology, Wroclaw Medical University, Wroclaw, Poland.
Background:
Y-Box-binding protein-1 (YB-1) acts as a transcription factor for multiple genes and is linked to DNA replication and repair, cell proliferation and resistance to cytostatic drugs.
Patients And Methods:
The prognostic value of YB-1 expression in primarily untreated malignant non-Hodgkin's lymphomas (NHLs) was examined using immunohistochemistry.
Results:
Expression of YB-1 was detected in 48 out of 56 NHLs, and the immunohistochemical reaction was localized exclusively in the cytoplasm. Expression of YB-1 did not correlate with clinicopathological variables. Patients with higher YB-1 expression had shorter progression-free survival during the entire period of observation (p=0.0434), as well as in the course of 30 months' observation (p=0.0253). Additionally, in the course of 50 months' observation, patients with higher expression of YB-1 demonstrated a shorter overall survival time (p=0.0383) and a shorter progression-free survival (p=0.0309).
Conclusion:
Elevated YB-1 expression may represent a new unfavorable prognostic factor.
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