Studies in global and local histogram-guided relaxation algorithms
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Updated: May 29, 2026

NMR 15N Relaxation Experiments for the Investigation of Picosecond to Nanoseconds Structural Dynamics of Proteins
Published on: November 1, 2024
P A Nagin1, A R Hanson, E M Riseman
1MEMBER, IEEE, Department of Ophthalmology, Tufts New England Medical Center, Boston, MA 02111.
Abstract:
An image segmentation algorithm based on histogram clustering and probabilistic relaxation labeling is explored. The algorithm is evaluated by means of a set of artificially generated test images with known parameters. Two sources of pixel labeling errors are revealed. The first derives from distribution overlap in the histogram and leads to fragmented or missing regions in a segmentation. The second derives from the gloal nature of the compatibility coefficients used in the relaxation process. The coefficients are shown to be insufficient to correct certain labeling errors and can even cause the destruction of fine image details during the course of the relaxation updating process. A potential solution to these problems is shown to be obtainable by using orientation dependent compatibility coefficients and localizing the scope of the algorithm to small subimages followed by a merging of the segmented subimages.
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