Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plasma oxytocin, early predictor of transient postoperative arginine vasopressin deficiency.

The Journal of clinical endocrinology and metabolism·2026
Same author

Ginkgo Biloba Extract Ameliorates Age-Related Mitochondrial Deficits in Human iPSCs and Their Derived Neurons and Astrocytes.

Antioxidants (Basel, Switzerland)·2026
Same author

Chronic Exposure to <i>Gelsemium</i> Preparations Alters Mitochondrial Bioenergetics, Neurite Outgrowth, and Akt/mTOR Signaling in Human Neuronal Cells.

International journal of molecular sciences·2026
Same author

Compensatory Intercellular Mitochondrial Transfer Improves Bioenergetics in P301L Tau-Affected Neuronal Cells.

Cells·2026
Same author

Acute and post-acute neurobehavioral responses to lysergic acid diethylamide in healthy subjects: a randomized controlled study.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same author

Post-abortion ban changes in contraceptive method choices, visit type, and patient zip codes in Indiana's statewide contraceptive access initiative: PATH4YOU.

Sexual & reproductive healthcare : official journal of the Swedish Association of Midwives·2026

Related Experiment Video

Updated: May 29, 2026

Circadian Entrainment of Drosophila Melanogaster
07:12

Circadian Entrainment of Drosophila Melanogaster

Published on: June 3, 2020

Aging and circadian disruption: causes and effects.

Steven A Brown1, Karen Schmitt, Anne Eckert

  • 1Department of Pharmacology and Toxicology, University of Zurich, Switzerland. steven.brown@pharma.uzh.ch

Aging
|August 27, 2011
PubMed
Summary
This summary is machine-generated.

Aging disrupts daily circadian rhythms and sleep patterns. Hormonal shifts may contribute to these age-related changes in circadian behavior and physiology.

Related Experiment Videos

Last Updated: May 29, 2026

Circadian Entrainment of Drosophila Melanogaster
07:12

Circadian Entrainment of Drosophila Melanogaster

Published on: June 3, 2020

Area of Science:

  • Chronobiology
  • Gerontology
  • Sleep Science

Background:

  • The relationship between aging and circadian behavior is bidirectional.
  • Circadian clock dysfunction is linked to age-related diseases.
  • Aging itself alters circadian rhythms and physiology.

Purpose of the Study:

  • To explore the role of aging in disrupting circadian behavior.
  • To investigate potential mechanisms behind age-related circadian disruption.
  • To examine the contribution of hormonal changes to these disruptions.

Main Methods:

  • Review of recent research on aging and circadian rhythms.
  • Analysis of homeostatic and circadian sleep regulatory mechanisms.
  • Exploration of potential hormonal influences.

Main Results:

  • Aging leads to changes and disruption in circadian behavior and physiology.
  • Altered homeostatic and circadian sleep regulatory mechanisms are implicated.
  • Hormonal changes are suggested as a potential contributing factor.

Conclusions:

  • Aging significantly impacts circadian behavior and sleep regulation.
  • Hormonal factors warrant further investigation in age-related circadian disruption.
  • Understanding these changes is crucial for addressing age-related health issues.