Related Experiment Video
Updated: May 29, 2026
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Incidence of hemodynamic depression after carotid artery stenting using different self-expandable stent types
Kouhei Nii1, Masanori Tsutsumi, Hiroshi Aikawa
1Department of Neurosurgery, Fukuoka University Chikushi Hospital, Chikushino, Fukuoka, Japan.
Insights
The type of self-expandable stent used in carotid artery stenting (CAS) may influence hemodynamic depression (HD) risk. Researchers compared Wallstent and Precise stents, finding a significant difference in postprocedural HD rates.
Area of Science:
- Cardiovascular Surgery
- Interventional Neurology
- Biomedical Engineering
Background:
- Severe carotid artery stenosis poses a significant risk of stroke.
- Carotid artery stenting (CAS) is a common treatment for severe carotid artery stenosis.
- Different stent designs may impact procedural outcomes.
Purpose of the Study:
- To compare the rates of hemodynamic depression (HD) and thromboembolism between two types of self-expandable stents during CAS.
- To evaluate the safety and efficacy of Wallstent (braided Elgiloy) versus Precise (slotted-tube Nitinol) stents in patients with severe carotid artery stenosis.
Main Methods:
- A comparative study of 95 CAS procedures in 87 patients with severe carotid artery stenosis.
- Patients received either Wallstent (52 procedures) or Precise stents (43 procedures).
- Hemodynamic parameters (blood pressure, pulse rate, neurological signs) and diffusion-weighted MRI for thromboembolism were assessed post-procedure.
Main Results:
- The overall incidence of hypotension, bradycardia, or both was 17.9%, 3.2%, and 11.6%, respectively.
- Postprocedural hemodynamic depression (HD) occurred in 23.1% of Wallstent procedures versus 44.2% of Precise stent procedures (p = 0.025).
- Thromboembolism rates were 26.9% for Wallstent and 34.9% for Precise stents, a non-significant difference.
Conclusions:
- The choice of self-expandable stent may influence the risk of procedural hemodynamic depression in CAS.
- Postprocedural HD was successfully managed with vasopressors and withholding antihypertensive agents.
- No major cardiovascular events were observed in any patient post-CAS.
Abstract:
The rates of hemodynamic depression (HD) and thromboembolism were compared in 95 carotid artery stenting (CAS) procedures performed in 87 patients with severe carotid artery stenosis using self-expandable braided Elgiloy stents (Wallstent) in 52 and slotted-tube Nitinol stents (Precise) in 43 procedures. The blood pressure, pulse rate, and neurological signs were recorded at short intervals during and after CAS. All patients underwent diffusion-weighted magnetic resonance imaging within 5 days after the procedure. The incidences of hypotension, bradycardia, and both were 17.9%, 3.2%, and 11.6%, respectively. The rate of postprocedural HD was 23.1% with Wallstent and 44.2% with Precise; the difference was significant (p = 0.025). No patient manifested major cardiovascular disease after CAS. Diffusion-weighted magnetic resonance imaging revealed thromboembolism after 26.9% and 34.9% of Wallstent and Precise stent placement procedures, respectively; the difference was not significant. The type of self-expandable stent placed may affect the risk of procedural HD in patients undergoing CAS. Postprocedural HD was resolved successfully by the administration of vasopressors and by withholding antihypertensive agents.
