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Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
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Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
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A population-based twin study on sleep duration and body composition.

Rong Liu1, Xin Liu, Lester M Arguelles

  • 1Mary Ann and J. Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children's Memorial Hospital and Children's Memorial Research Center, Chicago, Illinois, USA.

Obesity (Silver Spring, Md.)
|August 27, 2011
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Summary

Shorter sleep duration is linked to increased body fat and decreased lean mass in women, but not men. Sleep duration is mainly environmental, while body composition is largely genetic.

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Area of Science:

  • Human Physiology
  • Genetics
  • Epidemiology

Background:

  • Sleep duration is a critical health behavior.
  • Body composition influences metabolic health.
  • Understanding their interplay and genetic basis is important.

Purpose of the Study:

  • To investigate the relationship between sleep duration and body composition.
  • To estimate the genetic contribution to sleep duration and body composition.
  • To analyze these factors in a Chinese twin population.

Main Methods:

  • Cross-sectional analysis of 1249 individuals (738 men, 511 women).
  • Utilized anthropometric and DXA measures for body composition.
  • Employed multiple regression and structural equation modeling.

Main Results:

  • Shorter sleep duration associated with higher adiposity and lower lean mass in women, not men.
  • Heritability of sleep duration was ~0.27-0.29.
  • Heritability of body composition measures ranged from 0.56-0.73.

Conclusions:

  • Short sleep duration impacts body composition in women.
  • Sleep duration is primarily influenced by environmental factors.
  • Adiposity measures are predominantly influenced by genetic factors.